Title:
Associate Professor of Internal Medicine and Digestive Diseases, Director of the Gastroenterology Fellowship Program, University of Cincinnati

Education:

1981
B.A. (Biochemistry) Swarthmore College, Swarthmore, PA

1985
M.D. Harvard Medical School, Boston, MA

Postdoctoral Training:

Internships and Residencies:

1985-1986
Intern in Medicine, Brigham and Women's Hospital, Boston, MA

1986-1988
Resident in Medicine, Brigham and Women's Hospital, Boston, MA

Clinical and Research Fellowships:

1988-1991
Fellow in Gastroenterology, Brigham and Women's Hospital, Boston, MA

Licensure and Certification:

1986
State of Massachusetts License Registration

1988
American Board of Internal Medicine Certificate

1992
American Board of Internal Medicine, Gastroenterology Subspecialty Certificate

1998
State of Ohio License Registration

2003
American Board of Internal Medicine, Gastroenterology Subspecialty Re-Certification

Academic Appointments:

1985-1989
Clinical Fellow in Medicine, Harvard Medical School

1989-1991
Research Fellow in Medicine, Harvard Medical School

1991-1998
Instructor in Medicine, Harvard Medical School

1998-2002
Assistant Professor of Medicine, University of Cincinnati

2002-
Associate Professor of Medicine, University of Cincinnati

Hospital Appointments:

1991
Associate Physician, Brigham and Women's Hospital, Boston, MA

1991
Gastroenterology Staff Physician, West Roxbury V.A. Medical Center, West Roxbury, MA

1993
Consulting Staff in Hepatology, Children's Hospital, Boston, MA

1995
Consulting Staff in Gastroenterology, Dana-Farber Cancer Institute, Boston, MA

1996
Transplant Physician, Massachusetts General Hospital, Boston, MA

1998
Staff Physician, University of Cincinnati Medical Center, Cincinnati, OH

Awards and Honors:

1980
Stanley Adamson Prize in Chemistry, Swarthmore College

1981
Student Medalist to the American Society of Chemists

1981
B.A. in Biochemistry with Distinction, Swarthmore College

1981
Phi Beta Kappa, Swarthmore College

1981
Sigma Xi Scientific Research Society, Swarthmore College

1991
American Gastroenterological Association Senior Fellow Award

1991
American Association for the Study of Liver Diseases Trainee Travel Award

1991
Glaxo Research Institute Fellows Award

1998
Jerry S. Trier Award for Clinical Teaching in Gastroenterology, Brigham and Women’s Hospital

2003
The Ralph A. Giannella Award for Excellence in Clinical Teaching in Gastroenterology, University of Cincinnati

Major Hospital Committee Assignments:

1994 - 1998
Internship Selection Committee, Brigham and Women's Hospital

1996 - 1998
Internship Selection Sub-committee, Brigham and Women's Hospital

2000 - 2001
Associate Director, Gastroenterology Fellowship Training Program, University of Cincinnati

2000 -
Basic Research Committee, Department of Internal Medicine, University of Cincinnati

2000 -
Interviewer, Internship Selection Committee, University of Cincinnati

2001 -
Director, Gastroenterology Fellowship Training Program, University of Cincinnati

2003 -
Pathobiology and Molecular Medicine Graduate Program Committee, University of Cincinnati

Membership, Offices and Committee Assignments in Professional Societies:

1990-
Member, American Federation for Clinical Research

1992-
Member, Gastroenterology Research Group

1993-
Member, American Association for the Study of Liver Diseases

1997-1999
Basic Research Committee, American Association for the Study of Liver Diseases (Duties: establish guidelines and recommendations for basic science research relevant to liver diseases, review of grant applications, sponsorship of research conferences and symposia)

2000-
Member, American Gastroenterological Association

2000-2002
Member, Mid-West Gut Club

2000-2003
Ethics Committee, American Association for the Study of Liver Diseases

Editorial Boards and Peer Review:

1992 -
Invited Reviewer: New England Journal of Medicine, Journal of Clinical Investigation, Gastroenterology, Biochemistry, Hepatology, Blood, Biochemical Journal, Biochimica Biophysica Acta, Journal of Laboratory and Clinical Medicine, Archives of Biochemistry and Biophysics, Comparative Biochemistry and Physiology, Scandanavian Journal of Gastroenterology

2000 -
Contributor, Selected Summaries - Gastroenterology

2002 - 2004
Editorial Board - Hepatology

Major Research Interests:

1. Physiological functions of bilirubin (a bile pigment)
2. Mechanisms of delivery and transport of small hydrophobic (dislike of water) compounds by the liver
3. Pathophysiology of kernicterus (severe form of jaundice found in newborn babies)
   

Principal Clinical and Hospital Service Responsibilities:

1991-1998
Attending Physician, Medical Service, Brigham and Women's Hospital, Boston, MA

1991-1998
Hepatology and Spanish Gastroenterology Clinic, Brigham Medical Group, Brigham and Women's Hospital, Boston, MA

1992-1998
Attending Physician, Gastroenterology Service, West Roxbury Veterans Administration Medical Center, West Roxbury, MA

1993-1998
Attending Physician, Gastroenterology Consult Service, Brigham and Women's Hospital, Boston, MA

1993-1998
Hepatology Consultant, Liver Transplant Service, Living-Related Donor Program, Children's Hospital, Boston, MA

1996-1998
Attending Physician, Liver Transplant Service, Massachusetts General Hospital, Boston, MA

1998-
Attending Physician, Hepatology and Liver Transplant Service, University of Cincinnati Medical Center, Cincinnati, OH

1998-
Attending Physician, Medical Service, University of Cincinnati Medical Center, Cincinnati, OH

1998 -
Hepatology Clinic, University Internal Medicine Associates, University of Cincinnati, Medical Arts Building, Cincinnati, OH

2002 -
Attending Physician, Gastroenterology Consult Service, University of Cincinnati Medical Center, Cincinnati, OH

Self Report of Teaching

Local Contributions

Harvard Medical School
1990
Gastrointestinal Pathophysiology (Health Sciences Training Program)
Proctor for tutorial session
8 medical students
20 hours/year

1991-1996
Gastrointestinal Pathophysiology Course (New Pathway)
Tutorial Leader
8-9 medical students
40 hours/year

1992
Enteric Biology Course (Boston-area Gastroenterology Training Programs)
Lecturer
50-100 medical students, residents, and fellows
5 hours/year

1992-1998
Longitudinal Course in Clinical Medicine
Lecturer
6-15 medical students
20 hours/year

1995
Gastrointestinal Pathophysiology (Health Sciences Training Program)
Hepatology Case Discussant
40 medical students
5 hours/year

1996-1998
Gastrointestinal Pathophysiology (Health Sciences Training Program)
Tutorial Leader and Lecturer
40 medical students (8 in tutorial)
20 hours/year as Tutorial Leader; 5 hours/year as Lecturer

1997-1998
Integrated Human Physiology (New Pathway)
Focused Exercise Discussant
25 medical students
5 hours/year

1997-1998
Gastrointestinal Pathophysiology Course (New Pathway)
Case Discussions
15 - 20 medical students
5 hours/year

1997
Harvard Medical School Intensive Review of Internal Medicine
Case Presentation and Discussion
600 residents, practicing physicians
10 hours/year

Brigham and Women's Hospital
1990-1998
Gastroenterology Research Journal Club
Discussant
10-15 fellows, 5 - 10 staff physicians
5 hours/year

1991-1995
General Medical Service
Attending Physician
1-2 medical students, 2 interns, 1 resident
1 month/year

1991-1998
Department of Medicine Clinical Pathological Conference
Discussant
50-70 house staff, 20-30 staff physicians
5 hours/year

1991-1998
Department of Medicine Resident's Morning Report Conference
Discussant
30-40 residents
5 hours/year

1991-1998
Department of Medicine Morbidity and Mortality Conference
Discussant
50-70 house staff, 20-30 staff physicians
5 hours/year

1993-1998
Gastroenterology Consult Service
Attending physician
0-2 medical students, 1 resident, 1 - 2 fellows
1 month/year

1993-1998
Hepatology Clinic (Medical Resident Clinical Elective)
Attending physician
1 - 2 residents
½ day/week

1993-1997
Endoscopy Conference
Discussant
3 - 5 fellows, 8 - 10 staff physicians
5 hour/year

1996-1998
Gastrointestinal Emergencies Lecture Series
Lecturer
1-2 students, 1-2 residents, 8 - 12 fellows, 10 - 15 staff physicians
5 hours/year

1996-1997
Hepatology Journal Club
Discussant
3 - 5 fellows, 5 - 6 staff physicians
10 hours/year

1997-1998
Women's Health Center Clinical Conference
Lecturer
8 - 10 clinical support staff, 5 - 6 staff physicians
5 hours/year

1998
Clinical Pathology Lecture Series
Lecturer
20 - 30 residents, 5-10 staff physicians
5 hours/year

Massachusetts General Hospital
1996-1998
Liver Transplant Service (Hepatology Consultant)
Attending physician
1 - 2 residents, 1 fellow, 1 - 4 staff physicians
1 - 2 months/year

West Roxbury Veterans Administration Medical Center
1992
Gastroenterology Consult Service
Attending physician
1 fellow
1 month/year

University of Cincinnati Medical Center
1998-
Hepatology Inpatient/Consult Service
Attending physician
0-1 medical students, 0-1 residents, 1 fellow
1 - 2 months/year

1998-
General Medical Service
Attending Physician
1-2 medical students, 1-2 interns, 1 resident
1 month/year

1998-
Gastroenterology Research Conference
Lecturer
4 - 8 fellows, 5 - 10 staff physicians
5 hours/year

1999-
Internal Medicine Clinical Conference
Lecturer
30 - 40 house staff
5 hours/year

1999-
Internal Medicine Residents’ Journal Club
Discussant
10 - 20 house staff
5 hours/year

1999-
From the Molecule to the Bedside, Department of Internal Medicine Lecturer
20 - 30 fellows, 10 - 20 faculty
5 hours/year

1999-
Gastroenterology Journal Club
Discussant
4 - 6 fellows, 1 - 2 residents, 6 - 8 faculty
5 hours/year

1999-
Hepatology Clinic (Medical/Pediatric Residency Clinical Elective)
Attending physician
1 - 2 residents
½ day/week

1999-
Division of Digestive Diseases Summer Lecture Series
Lecturer
4 - 6 fellows, 1- 2 residents, 1 - 2 students
5 hours/year

1999-
Science in Clinical Medicine Lecture Series
Lecturer
20 - 30 residents, 10 - 20 students
5 hours/year

2000-
Pathobiology Journal Club
Discussant
10 - 20 doctoral students
5 hours/year

2000-
Pathobiology Graduate Program - Orientation “Chalk Talk”
3 - 5 doctoral students
2 hours/year

2001-
Resident’s Liver Disease Lecture Series
3 - 6 residents, 1- 2 fellows
20 hours/year

2000-
Pathobiology Journal Club
Moderator
10 - 20 doctoral students
50 hours/year

2001-
Medical Grand Rounds
Judge
20 - 30 residents
2 hours/year

2001-
Fellows’ Grand Rounds
Judge
20 - 30 residents
3 hours/year

2003-
Department of Internal Medicine Resident Recruitment
Speaker
75 - 100 students
2 hours/year

Cincinnati V.A. Medical Center
2000-
Internal Medicine Residents’ Board Review Lecture
Discussant
30 - 40 residents, 5- 10 students
5 hours/year

2000-
Internal Medicine Resident’s Morning Report
Discussant
5 - 10 residents
1 hour/year

Providence Hospital
2000-
Department of Family Medicine Residency Program Lecture Series
Lecturer
30 - 40 residents, 3 - 4 students
10 hours/year

Regional, National, and International Contributions

Invited Presentations

1992
Seminars in Gastroenterology, St. Elizabeth’s Hospital, Boston, MA

1993
Research Conference, Boston University School of Medicine, Boston, MA

1994
Gastroenterology Grand Round, Rhode Island Hospital, Providence, RI

1995
Invited Speaker, International Bilirubin Workshop, University of Trieste, Italy

Gastroenterology Pathophysiology Seminar, Brown University School of Medicine, Providence, RI

Gastroenterology Grand Rounds, Massachusetts General Hospital, Boston, MA

Research-In-Progress Colloquia, University of Massachusetts Medical Center, Worcester, MA

Medical Conference, Carney Hospital, Boston, MA

1996
Clinical Pathologic Conference, Case records of the Massachusetts General Hospital, Boston, MA

Seminars in Gastroenterology, St. Elizabeth's Hospital, Boston, MA

Medical Conference, Carney Hospital, Boston, MA

1997
Medical Grand Rounds (Co-speaker), Brigham and Women's Hospital, Boston, MA

Renal Division Didactic Teaching Conference, Brigham and Women's Hospital, Boston, MA

Gastroenterology Clinical Conference, University of Vermont, Burlington, VT

Gastroenterology Division Research Seminar, University of Cincinnati, Cincinnati, OH

Liver Research Center Seminar, Albert Einstein College of Medicine, Bronx, NY

1998
AASLD Basic Research Single Topic Conference, “Transmembrane and Intracellular Diffusion”, Airlie Conference Center, Warrenton, VA

1999
Gastroenterology Grand Rounds, Children’s Hospital, Cincinnati, OH

Department of Medicine Research Conference, University of Cincinnati, Cincinnati, OH

Moderator, Postgraduate Course, AASLD Annual Meeting, Dallas, TX, “Recognition and Screening of Liver Disease”

2000
Meet-the-Professor Luncheon Program, Digestive Diseases Week, San Diego, CA, “Approach to the Patient with Abnormal Transaminases”

Department of Pathology and Laboratory Medicine Research Seminar, University of Cincinnati, “The Role of Binding Proteins in Intracellular Lipid Transport”

Moderator, Early Morning Workshop, AASLD Annual Meeting, Dallas, TX, “Bilirubin Metabolism”

Invited Presenter, Department of Medicine, Clinicopathologic Conference, University of Cincinnati, Cincinnati, OH

2001
Visiting Professor Lecture Series, Division of Gastroenterology and Hepatology, Northwestern University, Chicago, IL

Division of Gastroenterology Research Seminar, University of Massachusetts, Worcester, MA

Digestive Diseases Research Seminar, University of Pennsylvania, Philadelphia, PA

Moderator, Early Morning Workshop, AASLD Annual Meeting, Dallas, TX, “Bilirubin Metabolism”

2002
Department of Medicine Clinicopathologic Conference, Brigham & Women’s Hospital, Boston, MA

Department of Medicine, Residents Morning Report, Brigham & Women’s Hospital, Boston, MA

2003
Faculty Discussant, Post DDW 2003 Review for the Practicing Gastroenterologist, University of Cincinnati College of Medicine, Division of Digestive Diseases, Cincinnati, OH

Moderator, Parallel Session, AASLD Annual Meeting, Boston, MA, “Hepatic Inflammation”

Faculty Discussant, AASLD 2003 Review, University of Cincinnati College of Medicine, Division of Digestive Diseases, Cincinnati, OH

2004
Invited Speaker, European Association for the Study of Liver Disease, International Bilirubin Workshop, The Molecular Basis of Bilirubin Encephalopathy and Neurotoxicity, University of Trieste, Italy

Invitied Speaker, Voet Symposium, Swarthmore College, Swarthmore, PA

Invited Speaker, Digestive Diseases Research Development Center Research Conference, Cincinnati Children’s Hospital, Cincinnati, OH

Invited Speaker, Nephrology and Hypertension Seminar Series, University of Cincinnati

Professional Leadership Roles Related to Teaching

1994
Invited Reviewer, Gastroenterology Section, Harrison's Principles of Internal Medicine, 13th ed.

1999
Co-Director, American Association for the Study of Liver Diseases Postgraduate Course: “Hepatology Into the Next Millennium”
Bibliography

Original Reports

1. Zucker SD, Storch J, Zeidel ML, Gollan JL. Mechanism of spontaneous transfer of unconjugated bilirubin between small unilamellar phosphatidylcholine vesicles. Biochemistry. 1992; 31: 3184 - 3192.
2. Zucker SD, Goessling W, Zeidel ML, Gollan JL. Membrane lipid composition and vesicle size modulate bilirubin intermembrane transfer: evidence for membrane-directed trafficking of bilirubin in the hepatocyte. J. Biol. Chem. 1994; 269: 19262 - 19270.
3. Zucker SD, Goessling W, Gollan JL. Kinetics of bilirubin transfer between serum albumin and membrane vesicles: insight into the mechanism of organic anion delivery to the hepatocyte plasma membrane. J. Biol. Chem. 1995; 270: 1074 - 1081.
4. Zucker SD, Goessling W, Ransil BJ, Gollan JL. Influence of glutathione S-transferase B (ligandin) on the intermembrane transfer of bilirubin: implications for the intracellular transport of nonsubstrate ligands in hepatocytes. J. Clin. Invest. 1995; 96: 1927 - 1935.
5. Abalak A, Zeidel ML, Zucker SD, Jackson AA, Donovan JM. Effects of submicellar bile salt concentrations on biological membrane permeability to low molecular weight non-ionic solutes. Biochemistry 1996; 35: 7936 - 7945.
6. Zucker SD, Goessling W, Hoppin AG. Unconjugated bilirubin exhibits spontaneous diffusion through model lipid bilayers and native hepatocyte membranes. J. Biol. Chem. 1999; 274: 10852 - 10862.
7. Zucker SD, Goessling W. Mechanism of hepatocellular uptake of albumin-bound bilirubin. Biochim. Biophys. Acta. (Biomembranes) 2000; 1463: 197 - 208.
8. Goessling W, Zucker SD. Role of apolipoprotein D in the transport of bilirubin in plasma. Am. J. Physiol. Gastrointest. Liver Physiol. 2000; 279: G347 - G356.
9. Zucker SD. Kinetic model of protein-mediated ligand transport: influence of soluble binding proteins on the intermembrane diffusion of a fluorescent fatty acid. Biochemistry 2001; 40: 977 - 986.
10. Zucker SD, Goessling W, Bootle EJ, Sterritt C. Localization of bilirubin in phospholipid bilayers by parallax analysis of fluorescence quenching. J. Lipid Res. 2001; 42: 1377 - 1388.
11. Zucker SD, Qin X, Rouster SD, Yu F, Green RM, Keshavan P, Feinberg J, Sherman KE. Mechanism of indinavir-induced hyperbilirubinemia. Proc. Natl. Acad. Sci. USA. 2001; 98: 12671 - 12676.
12. Weisiger RA, Zucker SD. Transfer of small molecules between intracellular membranes: roles of soluble binding proteins, distance, and time. Am. J. Physiol. Gastrointest. Liver Physiol. 2002; 282: G105 - G115.
13. Wang WW, Smith DLH, Zucker SD. Bilirubin inhibits iNOS expression and nitric oxide production in response to endotoxin in rats. Hepatology 2004; 40: 424 - 433.
14. Keshavan P, Schwemberger SJ, Smith DLH, Babcock GF, Zucker SD. Unconjugated bilirubin induces apoptosis in colon cancer cells by triggering mitochondrial depolarization. Int. J. Cancer 2004; 112: 433 - 445.
15. Zucker SD, Horn PS, Sherman KE. Serum bilirubin levels in the U.S. population: gender effect and inverse correlation with colorectal cancer. Hepatology 2004; 40: 827 - 835.
16. Keshavan P, Deem TL, Schwemberger SJ, Babcock GF, Cook-Mills JM, Zucker SD. Unconjugated bilirubin inhibits VCAM-1-mediated transendothelial leukocyte migration. J. Immunol. 2005; 174: 3709 - 3718.

Invited Reviews and Editorials

1. Zucker SD, Goessling W, Gollan JL. Intracellular transport of small hydrophobic compounds by the hepatocyte. Semin. Liver Dis. 1996; 16: 159 - 168.
2. Gollan JL, Zucker SD. Recent developments in hepatocyte transport of bilirubin and small hydrophobic ligands: role of membranes and cytosolic binding proteins. Jap. Pharmacol. Ther. 1996; 24: 251 - 253.
3. Zucker SD and Flieder A. Case records of the Massachusetts General Hospital: Case 1-1997. N. Engl. J. Med. 1997; 336: 118 - 125.
4. Zucker SD. Diet and colon cancer: strike out the bran. Gastroenterology 2000; 119: 590 - 591.
5. Zucker SD. Management of refractory ascites: are TIPS or taps tops? Gastroenterology 2001; 120: 311 - 312.
6. Pilla J, Zucker SD. Caesarian for C? Possibly... Gastroenterology 2001; 120: 1555 - 1556.
7. Zucker SD. The hepatitis B vaccine: sorting through the B.S. about M.S. Gastroenterology 2001; 120: 1880 - 1882.
8. Zucker SD. A potential new hepatitis agent: making SEN-se of the data. Gastroenterology 2001;121: 734 - 735.
9. Zucker SD. Whomsoever ignores the natural history of the hepatitis C virus is doomed to treat it. Gastroenterology 2002; 122: 578 - 579.
10. Zucker SD. Some TIPS for the prevention of recurrent variceal hemorrhage? Gastroenterology 2002; 123: 384 - 387.
11. Zucker SD. All KIDding aside with the use of lamivudine for hepatitis B. Gastroenterology 2002; 123: 1741 - 1743.
12. Chauhan SS, Zucker SD. Hypercholesterolemia in primary biliary cirrhosis: getting to the heart of the matter. Gastroenterology 2003; 124: 854 - 856.
13. Zucker SD. Is it HELLPful to consider the hanging LCHAD in pregnancy-associated liver disease? Gastroenterology 2003; 124: 1548 - 1550.
14. Doshi S, Zucker SD. Liver emergencies in pregnancy. Gastroenterol. Clin. N.A. 2003; 32: 1213 - 1227.
15. Morelli MS, Zucker SD. A role for the appendix in inflammatory bowel disease? Cut it out… Gastroenterology 2003; 125: 1270 - 1272.
16. Zucker SD. Can de-bugging the system prevent complications of cirrhosis? The answer may be NO. Gastroenterology 2004; 126: 926 - 928.
17. Zucker SD, Sherman KE. Beyond interferon for hepatitis C: living in the present while hoping for the future. Gastroenterology 2004; 126: 1487 - 1488.
18. Holt AF, Zucker SD. Hepatitis C infection with normal transaminases: is the treatment worse than the disease? Gastroenterology 2004; 127: 677 - 679.
19. Zucker SD. Ironing out the cryptic intestinal defect in hereditary hemochromatosis. Gastroenterology 2005; 128: 794 - 797.

Proceedings of Meetings

1. Crawford JM, Zucker SD, Gollan JL. Hepatic mechanisms of intracellular transport and glucuronidation of bilirubin. In: Bock KW, ed. Hepatic Metabolism and Disposition of Endo- and Xenobiotics. Lancaster: Kluwer Academic Publishers, 1991: 151 - 159.
2. Zucker SD, Whitmer D, Gollan JL. Rapid intracellular membrane-to-membrane transfer of small hydrophobic molecules. In: Verna R, Nishizuk Y. Biotechnology of Cell Regulation. New York: Raven Press, 1991: 375 - 383.
3. Zucker SD, Gollan JL. Membrane-solute interactions in the liver cell. Washington International Liver Conference (Washington, DC). Symposium Booklet. 1993, 27 - 28.
4. Zucker SD, Goessling W, Gollan JL. The role of cytosolic proteins and cellular membranes in the intracellular trafficking of bilirubin. International Bilirubin Workshop (Trieste, Italy). Symposium Booklet. 1995, 61 - 62.
5. Gollan JL, Zucker SD. A new voyage of discovery: transport through the hepatocyte. In: Transactions of the American Clinical and Climatological Association (Hot Springs, Virginia). Cadmus Journal Services. 1996, 48 - 56.
6. Zucker SD. Transmembrane and intracellular diffusion. In: Advances in Hepatic Transport: Molecular Mechanisms, Genetic Disorders, and Treatment. AASLD Basic Research Single Topic Conference (Warrenton, Virginia). Symposium Booklet. 1998, 31 - 35.
7. Zucker SD. How bilirubin enters the cell: addressing the confusion about diffusion. EASL International Workshop on The Molecular Basis of Bilirubin Encephalopathy and Neurotoxicity (Trieste, Italy). Symposium Booklet. 2004, 7 - 8.

Book Chapters

1. Zucker SD, Gollan JL. Copper metabolism and Wilson's disease: an "ion" recent advances. In: Thompson ABR, DaCosta LR, Watson WC, eds. Modern Concepts in Gastroenterology. New York: Plenum Medical Book Company, 1992: 223 - 262.
2. Zucker SD, Gollan JL. Wilson's disease: pathophysiology and therapy. In: Prieto J, Rodes J, Shafritz DA, eds. Hepatobiliary Diseases. Barcelona: Springer-Verlag, 1992: 801 - 834.
3. Zucker SD, Gollan JL. Cirrhosis. In: Rakel RE, ed. Conn's Current Therapy. Philadelphia: W.B. Saunders Company, 1993: 447 - 457.
4. Zucker SD, Gollan JL. Bleeding esophageal varices. In: Rakel RE, ed. Conn's Current Therapy. Philadelphia: W.B. Saunders, 1994: 450 - 456.
5. Zucker SD, Gollan JL. Cirrhosis. In: Rakel RE, ed. Conn's Current Therapy. Philadelphia: W.B. Saunders Company, 1994: 440 - 449.
6. Zucker SD, Gollan JL. Physiology of the liver. In: Haubrich WS, Schaffner F, eds. Bockus Gastroenterology, Fifth Edition. Philadelphia: W.B. Saunders Company, 1995: 1858 - 1905.
7. Zucker SD, Gollan JL. Wilson's disease and hepatic copper toxicosis. In: Zakim D, Boyer TD, eds. Hepatology: A Textbook of Liver Disease, 3rd ed. Philadelphia: W.B. Saunders Company, 1996: 1405 - 1438.
8. Gollan JL, Zucker SD. Wilson's disease: diagnosis, clinical course and therapy. In: Bianchi L, Schmid R., eds. Acute and Chronic Liver Diseases: Molecular Biology and Clinics. Lancaster: Kluwer Academic Publishers, 1996: 178 - 191.
9. Saxena R, Zucker SD, Crawford JM. Anatomy and physiology of the liver. In: Zakim D, Boyer TD, eds. Hepatology: A Textbook of Liver Disease, 4th ed. Philadelphia: Saunders, 2003: 3 - 30.
10. Wang WW, Zucker SD. Bilirubin and jaundice. In: Johnson LR., ed. Encyclopedia of Gastroenterology. San Diego: Academic Press, 2003: 219 - 222.

Book Editor

1. Zucker SD, Section Editor, Gastroenterology. In: Thaler DE, Hope, RA, Longmore JM. Oxford Handbook of Clinical Medicine - American Edition. Oxford University Press, New York 1999.
2. Zucker SD, Section Editor, Gastroenterology. In: Thaler DE, Hope, RA, Longmore JM. Oxford Handbook of Clinical Medicine - Second American Edition. Oxford University Press, New York 2003.

Abstracts and Symposia

1. Zucker S, Connors P, Crawford J, Carr-Locke D. Initial clinical experience with percutaneous liver biopsy using the Bard monoptyTM instrument [Abstract]. Am J Gastroenterol. 1991; 86:1343.
2. Zucker S, Narciso J, Storch J, Zeidel M, Gollan J. Dansyl-labeled taurocholate transfer between phospholipid vesicles: implications for the rapid hepatocellular transport of bile salts [Abstract]. Gastroenterology 1992; 102:914A.
3. Zucker SD, Narciso JP, Zeidel ML, Crawford JM, Gollan JL. Aqueous transfer of dansyl-labeled taurocholate between phospholipid vesicles: implications for intracellular transport of bile salts [Abstract]. Symposium on Bile Acids: 1993 and the Future 1993; Abstract Booklet, p. 147.
4. Zucker SD, Narciso JP, Zeidel ML, Crawford JM, Gollan JL. Aqueous transfer of dansyl-labeled bile salts between phospholipid vesicles: effects of hydrophobicity on membrane interactions [Abstract]. Gastroenterology 1993; 104:A1025.
5. Cohen DE, Leonard MR, Zucker SD, Carey MC. Modeling the rate limiting step in biliary phosphatidylcholine (PC) secretion: bile salts (BS) activate PC-transfer protein at the endoplasmic reticulum [Abstract]. Gastroenterology 1993; 104:A889.
6. Hoppin AG, Goessling W, Gollan JL and Zucker SD. The role of lipoproteins and erythrocyte membranes in the transport of organic anions in blood [Abstract]. Gastroenterology 1995; 108:A1086.
7. Zucker SD, Hoppin AG. Unconjugated bilirubin exhibits spontaneous transmembrane flip-flop [Abstract]. Hepatology 1996; 24: 132A.
8. Zucker SD, Bootle EJ. Localization of bilirubin in lipid bilayers by fluorescence parallax analysis [Abstract]. Hepatology 1996; 24: 604A.
9. Goessling W, Zucker SD. Hepatocellular uptake of bilirubin occurs via rapid transmembrane diffusion [Abstract]. Hepatology 1997; 26: 385A.
10. Goessling W, Zucker SD. Human apolipoprotein D binds bilirubin with high affinity and facilitates bilirubin association with plasma HDL [Abstract]. Hepatology 1997; 26: 385A.
11. Goessling W, Zucker SD. Bilirubin uptake by hepatocytes occurs via rapid transmembrane diffusion and does not require specific transport proteins [Abstract]. AASLD Basic Research Single Topic Conference; June 1998.
12. Zucker SD, Qin X, Yu F, Goessling W. Inhibition of breast cancer cell proliferation by unconjugated bilirubin is associated with enhanced expression of apolipoprotein D and increased nuclear translocation of transcription factor NF-κB [Abstract]. Hepatology 1999; 30: 498A.
13. Zucker SD, Qin X. Effect of bovine serum albumin on the intermembrane diffusion of 12-anthroyloxy stearate: implications for the role of soluble proteins in the intracellular transport of hydrophobic ligands [Abstract]. Hepatology 1999; 30: 464A.
14. Zucker SD. Effect of soluble binding proteins on the intermembrane diffusion of fluorescent fatty acids: influence of the mechanism of ligand-protein interaction [Abstract]. FASEB Summer Research Conference, July 2000.
15. Zucker SD, Goessling W. Bilirubin-membrane interactions: bilayer localization of unconjugated and taurine-conjugated bilirubin as determined by parallax analysis of fluorescence quenching [Abstract]. Hepatology 2000; 32: 427A.
16. Zucker SD. The effect of fatty acid binding proteins on the intermembrane diffusion of 12-anthroyloxy stearate is determined by the mechanism of ligand-protein interaction [Abstract]. Hepatology 2000; 32: 441A.
17. Zucker SD, Qin X, Rouster SD, Yu F, Green RM, Feinberg J, Sherman KE. Mechanism of indinavir-induced hyperbilirubinemia [Abstract]. Gastroenterology 2001;120: A-45.
18. Wang W, Qin X, Yu F, Zucker SD. Unconjugated bilirubin attenuates the inflammatory response through an NF-κB-dependent pathway [Abstract]. Gastroenterology 2002;122: A-636.
19. Keshavan P, Zucker SD. Role of bilirubin in regulating colonic adenocarcinoma cell growth [Abstract]. Gastroenterology 2002;122: A-242.
20. Scheidler MD, Zucker SD. Utility of cytomegalovirus (CMV) tissue culture and early antigen in the diagnosis of CMV hepatitis in liver transplant recipients [Abstract]. Hepatology 2002; 36: 661A.
21. Wang W, Chen H, Smith DL, Keshavan P, Rabbani LE, Zucker SD. Adventitial delivery of unconjugated bilirubin is not preventive against intimal hyperplasia in rat carotid arterial injury [Abstract]. Hepatology 2002; 36: 450A.
22. Harmon G, Osmer E, Zucker SD, Green RM. Biliurbin potentiates gene expression of hepatic UDP-glucuronosyltransferase (UGT1A1) in H35 cells [Abstract]. Hepatology 2002; 36: 340A.
23. Keshavan P, Deem TL, Cook-Mills JM, Zucker SD. Unconjugated bilirubin inhibits lymphocyte migration across endothelial monolayers [Abstract]. Gastroenterology 2003; 124: A-727.
24. Wang WW, Smith, DLH, Zucker SD. Bilirubin regulates iNOS expression and nitric oxide production in endotoxemia [Abstract]. Hepatology 2003; 38: 251A.
25. Keshavan P, Deem TL, Schwemberger SJ, Babcock GF, Cook-Mills JM, Zucker SD. Unconjugated bilirubin inhibits VCAM-1-mediated transendothelial leukocyte migration [Abstract]. Gastroenterology 2005; in press.
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